He acknowledges there isn’t much research yet on the effect of injecting the drug, but it appears that when bupropion enters the bloodstream, it leads to a necrotizing, or tissue-destroying effect. Antidepressants (bupropion) Wellbutrin Overnigt Shipping This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.""A countrywide shortage of a common antidepressant medication has caused alarm among doctors, pharmacists and patients with mental illnesses.