The goal of the Ara Parseghian Medical Research Fund (APMRF) is to raise funds that will support research projects to find a treatment for Niemann-Pick Type C (NPC) disease.

This funding supports an international research program:

  • To expedite a treatment for NPC disease
  • To promote collaborative research efforts among the world’s leading experts in cholesterol metabolism, cell biology, neurobiology, genetics, pharmacology and other areas of science
  • To study similar and further the cause of other neurodegenerative diseases as well as cholesterol storage disorders

The research program is directed by a Scientific Advisory Board (SAB) of internationally acclaimed scientists. Ninety percent of every dollar contributed to the Foundation is directed to medical research, with only ten percent supporting administrative costs.

Medical research is costly, but it’s our hope in saving the lives NPC patients. The Parseghian Foundation is currently funding 8 labs across the Globe.  Grants are awarded up to $100,000 per year.

For the thousands of children and young adults worldwide who are afflicted with NP-C and for the 60,000 children who have other neurodegenerative diseases, the APMRF’s goal means life. This research effort is a race against time.

Learn more about our currently funded and previously funded grants.


Applying for Grants in 2017:

The Ara Parseghian Medical Research Fund (APMRF) at Notre Dame (ND) is pleased to announce we will be accepting grant requests for the 2017 grant cycle.  The mission of the APMRF is to promote research that furthers understanding of the molecular basis of Niemann Pick Type C (NPC) disease and targets development of novel strategies to treat and/or cure the disease.  For more information please read the rest of the RFP including the General Information section.

For the 2017 Request for Proposals (RFP) there will be two levels of grants awarded:

  • Research grants will provide support for up to $100,000 for the period of one year beginning July 1, 2017.
  • A few collaborative research grants will provide support for up to $250,000 for the period of two years beginning July 1, 2017. These grants will be targeted to multidisciplinary, collaborative research teams that involve two or more laboratories and primarily focused on translation of novel therapeutic strategies.

Please submit a letter of intent (LOI) of no more than 2 pages to skassen@nd.edu by March 1st, 2017. Your letter of intent should include the name of your organization, a description of the project, the amount needed or requested, and the qualifications of the project staff. We request that all LOIs be formatted with font size of 11pt. or greater and use 1-inch margins.

*Please make sure you receive an email confirmation from me with in 24 hours of your submission.  If you do not receive one, please call me at 574-631-4689.

Deadline for submission of the letter of intent is March 1, 2017.

The LOI will be reviewed by the SAB and they will make recommendations for who will be invited to submit a full grant application.  All LOIs will be reviewed by April 1, 2017.

For those invited to submit a full grant application the deadline will be May 1, 2017.


 General Information:

A) Background and Purpose
The purpose of the Ara Parseghian Medical Research Fund (APMRF) is to promote research that is targeted toward understanding the molecular basis of Niemann Pick Type C (NPC) disease and developing novel therapeutic strategies to treat and/or cure the disease. In addition, because NPC disease is a cholesterol storage disease, it is anticipated that these studies should provide fundamental insight into cholesterol homeostasis and may serve to increase understanding of atherosclerosis and other cholesterol-related disorders. As part of our mission, the foundation will also seek to foster open collaboration between investigators currently working on NPC disease-related projects.

The Scientific Advisory Board (SAB) of the APMRF is responsible for formulating the direction of research related to NPC disease. As such, the SAB will generate a series of scientific priorities and set forth specific research funding announcements (RFA’s). Investigators are encouraged to respond directly to these RFA’s. However, novel applications in NPC-related topics will also be considered under exceptional circumstances. Grant applications will be reviewed by the SAB via an expedited review mechanism. All funded projects will be reviewed by the SAB on an annual basis.

B. Authority For Making Grants

Grants are made by the APMRF selection committee acting on the recommendations of the SAB.

APMRF reserves the right to cancel a grant for cause at any time and require the return of any unexpended funds.

C. Eligibility For Grants

Grants are awarded to qualified institutions and organizations within the United States and abroad.

D. Duration Of Awards

Research grant awards are for a maximum of one year, but some proposals will be considered for a two year period.

Investigators are encouraged to apply to other sources of support after the initial one funding period; however, they may also reapply for continued funding for either their current or a new research project.

E. Award Contract

Any approved awards will only be granted upon the signing of a grant award letter with the APMRF at ND.  Please go to this link to review a sample award letter template.  These include language regarding 1) the purpose of the grant, 2) use of grant funds, 3) subgrants and subcontracts, 4) reports and expectations, 5) report format, 6) record maintenance and inspection, 7) compliance, 8) indemnification, 9) publications, 10) intellectual property, 11) grant announcements, public reports and use of university name and logo, 12) equipment, 13) counterparts; original, 14) assignment; 15) independent contractors, 16) entire agreement, severability and amendment, 17) law and jurisdiction.